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Solving the Breast Cancer Puzzle

Investigators report headway against breast cancer, the disease that worries some women more than any other. The suspects they've identified--from heredity to lifestyle--may point you toward precautions.

Breast cancer is the most common cancer among women, except for nonmelanoma skin cancers. After lung cancer, it is the second-leading cause of cancer death in women, according to the American Cancer Society (ACS).

Anatomy of an enigma

To understand the puzzle of breast cancer, you must understand how the breasts work.

The breasts consist of glandular tissue surrounded by fat. The glandular tissue secretes milk after a woman gives birth.

During the monthly menstrual cycle, the body begins the complex process of preparing the breast to make milk. The ovaries release hormones called estrogens that stimulate breast cells. The days before menstruation you may experience swollen, painful breasts that return to normal once the menstrual period begins, or that continue to grow if a woman is pregnant and will soon nourish a baby.

Month in, month out, breast cells change in response to hormonal stimulation throughout the reproductive years.

Longer menstrual life

Experts believe this constant stimulation presents problems. We do know that breast tissue is estrogen-sensitive, and we know that estrogen and progesterone are hormones that can promote breast cancer cell growth. We also know that the greater the total number of ovulations a woman has in her lifetime, the greater the risk of breast cancer. (This increase in risk may be due to greater lifetime exposure to the hormones estrogen and progesterone.) 

That means women who start menstruating early, before age 12, and have a late menopause, after age 55, run a higher risk. So do women who have had no children, or who had their first child after age 30.

With estrogen and other hormones as catalysts, breast cells continually receive the signal to change.

That puts the breast in a class with such other highly active anatomy as the intestinal tract, where cancer also is common. It seems "active" cells have more chances to change, compared with inactive cells such as fat cells in the buttocks.

But what turns rapidly changing cells into cancer? Two women may share a seemingly identical profile, but one will get the disease and the other will not.

To solve that puzzle, researchers must continue to follow the clues.

The usual suspects

Here are some usual suspects that increase a woman's risk of developing breast cancer:

  • Weight and lifestyle. Overweight women seem more prone to breast cancer, especially overweight postmenopausal women. Fat cells can make and store estrogen, perhaps increasing this hormone's effect on the breast. Alcohol consumption can raise estrogen and increase risk, too. So can a sedentary lifestyle.

  • Family history and genetics. A woman's risk increases if close blood relatives of either parent have had breast cancer. Scientists have discovered mutations in 2 genes, BRCA1 and BRCA2, which they blame for about 5% to 10% of breast cancer in the general population, but they have found higher rates in women of Ashkenazi Jewish ancestry. Around 80% of women who carry these genes will likely develop the disease. But experts believe just a fraction of the female population has one of these 2 genes. Other mutations may occur that affect the kinds of proteins that the breast cancer cells produce. These mutations affect the tumor's response to different therapies. For example, some breast cancers make too much of a protein called HER2, which makes cancers grow faster. Different drugs target some of the most common types of mutations that occur in breast cancers. 

  • Race/ethnicity. White women get breast cancer at a higher rate than African-American women, but African-American women are more likely to get breast cancer before they are 40. African-American women also are more likely to die from it at any age. 

  • Personal history. "Lumpy" breasts, common among women, do not increase breast cancer risk. Several breast conditions are harmless, including fluid-filled sacs called cysts and solid round tumors called fibroadenomas. But cysts in 2 breast conditions, atypical ductal hyperplasia or atypical lobular hyperplasia, do increase cancer risk. Any unusual breast lump must be checked by a doctor; 80 percent prove to be benign. Previous cancer in 1 breast also is a risk factor.

  • Your world. On the environmental front, research is under way to look into the roles of diet, tobacco, pesticides, engine exhausts, and contaminants in food and water. Scientists have not confirmed any absolute links.

Reducing your risk

Over their lifetime, 1 in 8 women will get breast cancer. Here's how you can help decrease your risk:

  • Get regular mammograms and breast exams. Talk with your doctor to see how often you should be tested and how young you should start. These are decisions that may be influenced by your risk factors. Mammograms can detect a lump far earlier than you or a doctor can feel it.

  • Think low-fat and high-fiber. Include 2 1/2 cups or more of fruits and vegetables per day. A healthy, nutritious diet may help decrease the risk for several cancers.

  • Try to keep your weight normal. A recommended range is a body mass index (BMI) of 18.5 to 24.9. To calculate your BMI, figure your weight in kilograms and divide it by your height in meters squared (kg/m2).

  • Exercise. Regular exercise will help keep your weight down and can have many other health benefits.

  • Limit alcohol. If you drink alcohol, stop at 1 drink a day (or less).

  • Carefully weigh the benefits of hormone therapy. Considering hormone therapy (HT) after menopause? Although HT may offer benefits for menopausal symptoms and in the prevention of osteoporosis, it increases other health risks. Talk to your health care provider to see what is best for you.

Preventive options?

Talk to your doctor about your breast cancer risk. If you are at increased risk, there may be some things you can do to help reduce your chances of developing breast cancer. Before deciding if these options are right for you, talk with your doctor about how much any of these approaches might lower your risk.

  • Tamoxifen. This anti-estrogen drug has long been used to treat breast cancer, but studies have found preventive benefits, as well. Still, this drug can have serious side effects, including a higher risk of endometrial cancer and blood clots. Women should talk to their doctors about the possible benefits and risks of tamoxifen before deciding if it is right for them.

  • Raloxifene. This "designer estrogen" (brand name Evista) can cut the risk for breast cancer as well as tamoxifen while imitating estrogen's benefits for your bones and heart. Like tamoxifen, it may increase the risk for blood clots. It can only be used in women who have been through menopause. 

  • Aromatase inhibitors. This class of drugs decreases the body's estrogen by blocking the conversion of naturally produced androgen into estrogen. After menopause, most of woman's estrogen is made in tissues outside the ovaries from androgen. Currently, 3 of these drugs are approved by the FDA: anastrazole (Arimidex), exemestane (Aromasin), and letrozole (Femara). Possible side effects are decreased bone density and joint pain and stiffness. These drugs are approved to help keep breast cancer from coming back after treatment. They are being studied for use as drugs to help reduce breast cancer risk, but none of them are approved to help prevent breast cancer from developing.

  • Prophylactic mastectomy. For women with a family history of breast cancer, removal of both breasts may reduce the risk. This option should be considered only after trying other preventive treatments and counseling. There is no way to know if this surgery will benefit a particular woman. It is recommended that women get a second opinion before deciding to have this surgery.

 

 

 

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